Influence of acid-citrate-dextrose anticoagulant on blood quality in retransfusion systems after total knee arthroplasty.

The authors propose to refrain from ACD anticoagulation in orthopedic postoperative autotransfusion. Their conclusion is not convincing. Products of activation of coagulation and fibrinolysis were not tested, although the main reason for anticoagulation is to decrease those dangerous contaminants. How can the authors justify to a patient with relevant blood loss the failure of the […]

Salmonella sepsis caused by a platelet transfusion from a donor with a pet snake.

This article is interesting but the authors’ conclusion fails to satisfy. Both the donor and his daughter suffered from diarrhea 2 to 3 weeks before donation and were successfully treated with antibiotics. Blood donation was thus unacceptable. One should conclude that donors having suffered from unclear diarrhea for 3 to 4 weeks (not donors having […]

Blood use in cerebrovascular neurosurgery.

This paper has sufficient data with regards to red cell transfusion in cerebrovascular neurosurgery that allows rational recommendations to be made with regards to a blood ordering scheme for such patients. Such recommendations are long overdue. – M. Contreras.

Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle – An efficacy study in the hamster.

This is another study on the potential benefits of an oxygen carrier (ultrapurified polymerized bovine hemoglobin solution) on tissue perfusion after hypervolemic infusion or exchange transfusion of 50% of blood volume in a hamster model. The authors have shown that the infusion of the hemoglobin solution actually decreases (slightly) mean tissue pO2 but homogenizes local […]

Influence of storage on red blood cell rheological properties.

Growing evidence shows that transfusion of stored red cells may well harm patients. Studies are therefore necessary in order to help establish the reasons for this negative effect. Decrease of deformability of red cells during storage may be one explanation. Reduced perfusion of the capillary bed may be the consequence of reduced deformability of red […]

The effects of hemoglobin glutamer-200 (Bovine) on the microcirculation in a canine hypovolemia model: A noninvasive computer-assisted intravital microscopy study.

The authors present a dog model of hemorrhage (similar to 40% blood loss) that will be useful for the evaluation of treatment(s) of severe hypovolemia. In this case, hemoglobin glutamer-200 was used to restore the circulating blood volume and oxygen carrying capacity. However, the authors’ conclusions are limited by the small number of dogs studied […]