Hydroxyethyl starch (HES) 130/0.4 provides larger and faster increases in tissue oxygen tension in comparison with prehemodilution values than HES 70/0.5 or HES 200/0.5 in volunteers undergoing acute normovolemic hemodilution.
This prospective randomized double-blinded crossover study demonstrated that hydroxyethyl starch specifications (in vitro molecular weight, degree and pattern of substitution) could significantly alter muscular tissue oxygen tension used as an indicator of blood rheology. The better results obtained with HES 130/0.4 might be attributed to the optimum “in vivo” molecular size achieved by this hydroxyethyl […]
Influence of cell-free Hb on local tissue perfusion and oxygenation in acute anemia after isovolemic hemodilution.
This experimental study shows that, in hamsters, exchange transfusion with polymerized bovine hemoglobin to a hemoglobin content of 6.7 g/dL failed to maintain tissue oxygenation and in-vivo functional capillary density (according to this reviewer, possibly because PBH caused vasoconstriction). The message is important: we know hemoglobin solutions can transport oxygen but clinicians will want to […]
Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism.
Interesting article evaluating the place of a hemoglobin-based oxygen-carrying solution in the resuscitation of severe hemorrhagic shock. – P. Van der Linden.