Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial.
This is a very important, landmark article describing for the first time the efficacy of an antifibrinolytic, tranexamic acid (TA), to decrease mortality in bleeding trauma patients. The study enrolled […]
Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials.
The etiology of severe hemorrhage associated with trauma includes coagulopathy, hypothermia, acidosis, as well as platelet dysfunction, in addition to the direct effect of trauma itself. This important large international […]
First military use of activated Factor VII in an APC-III pelvic fracture.
This case report illustrates the efficacy and benefit of using rFVIIa in controlling severe bleeding associated with trauma which resulted in severe pelvic and sacral fracture. The authors advocate further […]
Factor VIIa for correction of traumatic coagulopathy.
This paper reports the use of rFVIIa in 81 patients who suffered with traumatic bleeding over a period of 30 months in a large trauma center. The center set guidelines […]
A novel hemostatic agent: the potential role of recombinant activated factor VII (RFVIIa) in anesthetic practice.
This is an excellent literature review on the adjuvant use of rFVIIa in treating severe bleeding associated with surgical procedures in non-hemophiliac patients. It gives an overview of the mechanism […]
HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury.
This experimental study highlights the potential beneficial therapeutic effect of a hemoglobin-based oxygen carrier (HBOC) used as a resuscitation fluid during severe traumatic shock. In contrast to colloid (high molecular […]
Updates in the management of severe coagulopathy in trauma patients.
This is a very good review on the pathophysiological changes which occur following trauma and the associated coagulopathy. Thrombo-cytopenia, hypotheromia, acidosis, and fibrinolysis are among factors which lead to coagulopathy. […]
Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock: A pilot study.
This is an interesting work showing the efficacy of rFVIIa in controlling post traumatic hemorrhage in an animal model, especially after the publication of several case reports of the effective […]
Release of interleukin-10 by reinfusion of salvaged blood after knee arthroplasty.
Another confirmation that cell washing is essential to eliminate mediators contaminating wound blood, and that changes in interleukin levels are mainly dependent on other factors. – E. Hansen.
Recombinant activated factor VII for adjunctive hemorrhage control in trauma.
This is a relatively new area for using rFVIIa, which is to treat uncontrolled haemorrhage in patients with severe trauma, following the earlier report of using rFVIIa successfully in treating […]
Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism.
Interesting article evaluating the place of a hemoglobin-based oxygen-carrying solution in the resuscitation of severe hemorrhagic shock. – P. Van der Linden.