Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses.
This is one of the largest PRCTs of colloid vs. colloid to date. It forms the basis of the new European dose limit for HES 130/0.4 at 50 mL/kg. Trials over 100 patients, with a power calculation and at least some attempt at blinding are a rare treat. The discussion is balanced and refreshing in […]