Transfusion Practice

21st Annual NATA Symposium

21st Annual NATA Symposium, Athens 2020The 21st Annual NATA Symposium on Patient Blood Management, Haemostasis and Thrombosis will take place on April 23-24, 2020 in Athens, Greece.

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21st Annual Symposium General Information

Focused Update: Perioperative Management of Jehovah’s Witness Patients in Relation to Their Refusal of Allogeneic Blood Transfusion

Jehovah's Witness (JW) patients strictly refuse allogeneic blood transfusion (red blood cells, plasma and platelets), even in the presence of life-threatening anemia and/or coagulopathy. However, today JW patients can undergo major surgical procedures without facing an excessive risk of death—provided that a prospectively conceived and structured perioperative management is applied.

In a Nataonline Focused Update, Prof. Oliver Habler, Department of Anesthesiology, Surgical Intensive Care Medicine and Pain Therapy, Krankenhaus Nordwest GmbH, Frankfurt, Germany, reviews the perioperative management of JW patients with emphasis on the following cornerstones: (1) the preoperative optimization of cardiopulmonary status and the correction of preoperative anemia and coagulopathy, (2) the perioperative collection of autologous blood, (3) the minimization of perioperative blood loss and (4) the utilization of the organism’s natural tolerance to anemia and its acute accentuation in the case of life-threatening anemia.

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Focused update: The management of massive hemorrhage/transfusion in civilian trauma

The management of massive hemorrhage/transfusion in trauma has evolved considerably in the past few years. Based on a consensus established in 2005, several civilian trauma centers have adopted a restrictive approach to the administration of crystalloids in view of minimizing hemodilution, along with the transfusion of red blood cells (RBC), fresh frozen plasma (FFP) and platelet concentrates (PC) in a 1:1:1 ratio. In a Nataonline Focused Update, Professor Jean-François discusses the evidence supporting this strategy.

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From the Literature

Jul 17, 2019

Published: May 2019

Vlot EA, Verwijmeren L, van de Garde EMW, Kloppenburg GTL, van Dongen EPA, Noordzij PG

Intra-operative red blood cell transfusion and mortality after cardiac surgery.
BMC Anesthesiol 2019;19:65.

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NATA REVIEW:
Many studies have shown an association between transfusion and adverse events, including short- and long-term...
REVIEW by:
M. Pavesi

Published: May 2019

Althoff FC, Neb H, Herrmann E, et al.

Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
Ann Surg 2019;269:794-804.

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NATA REVIEW:
This systematic review and meta-analysis focused on the implementation of a comprehensive PBM approach. Studies...
REVIEW by:
B. Froessler

Published: Jan 2019

Curley A, Stanworth SJ, Willoughby K, et al.

Randomized trial of platelet-transfusion thresholds in neonates.
N Engl J Med 2019;380:242-251.

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NATA REVIEW:
In this multicentre trial, infants born at less than 34 weeks of gestation and in whom severe thrombocytopenia...
REVIEW by:
T. Haas

Published: Sep 2018

Mazer CD, Whitlock RP, Fergusson DA, et al.

Six-month outcomes after restrictive or liberal transfusion for cardiac surgery.
N Engl J Med 2018;379:1224-1233.

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NATA REVIEW:
In this follow-up article to the TRICS III trial, the authors report the clinical outcomes of moderate- to high-risk...
REVIEW by:
J.-F. Hardy

Published: Sep 2018

Goel R, Patel EU, Cushing MM, et al.

Association of perioperative red blood cell transfusions with venous thromboembolism in a North American registry.
JAMA Surg 2018;153:826-833

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NATA REVIEW:
An association between red blood cell (RBC) transfusion and increased incidence of perioperative complications...
REVIEW by:
D. Faraoni

Published: Apr 2018

Roubinian NH, Hendrickson JE, Triulzi DJ, et al.

Contemporary risk factors and outcomes of transfusion-associated circulatory overload.
Crit Care Med 2018;46:577-585.

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NATA REVIEW:
Recently, a joint working group of members of the International Haemovigilance Network, the International Society...
REVIEW by:
C. So-Osman