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Mechanism of factor VIIa-dependent coagulation in hemophilia blood.

The mechanism of inducing hemostasis by factor VII (FVII) in hemophilia patients with inhibitors is not fully understood. Tissue factor (TF) and FVII are required to form a small concentration of thrombin (initiation phase) followed by increased activation of clotting factors and formation of a solid clot (propagation phase). This paper studies a model for […]