Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage.
This is an overview on the mechanism of action of rFVIIa and its role in hemostasis. rFVIIa directly activates FX, increases thrombin activation on activated platelets, and leads to generation […]
Recombinant human transgenic antithrombin in cardiac surgery: a dose-finding study.
This is a very important paper in two ways. First, it highlights ongoing activation of hemostasis in the postoperative period as demonstrated by the control group. The scale of Figure […]
Successful use of recombinant activated factor VII for trauma-associated hemorrhage in a patient without preexisting coagulopathy.
This is a detailed first case report in the United States on using recombinant activated factor VIIa in treating massive uncontrollable bleeding following stab wound trauma to the liver in […]