This is an important observational study which points towards higher mobidity and mortality in patients with acute coronary syndromes who undergo transfusion. The results obtained, though not definitive due to the nature of the study, strongly suggest the need for a randomized controlled clinical trial of restrictive versus liberal transfusion in this patient population.

– Marcela Contreras

A definite conclusion cannot be drawn from this study as observational and retrospective studies do not provide unbiased results. One should read the associated Editorial by Hebert and Fergusson.

– Volker Kretschmer