Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage.
This is an overview on the mechanism of action of rFVIIa and its role in hemostasis. rFVIIa directly activates FX, increases thrombin activation on activated platelets, and leads to generation […]
Possible role of recombinant activated factor VII (RFVIIa) in the control of hemorrhage associated with massive trauma.
This is a report on the largest series on the use of rFVIIa in treating patients suffering from uncontrolled bleeding as a result of trauma in spite of surgical treatment […]
Recombinant human transgenic antithrombin in cardiac surgery: a dose-finding study.
This is a very important paper in two ways. First, it highlights ongoing activation of hemostasis in the postoperative period as demonstrated by the control group. The scale of Figure […]
Aprotinin in orthotopic liver transplantation: Evidence for a prohemostatic, but not a prothrombotic, effect.
This study supports the hypothesis that aprotinin is an anticoagulant which prolongs the aPTT and has no or marginal risks of thromboembolic complications. – Wulf Dietrich.