Review articles are interesting but, unfortunately, do not add to existing knowledge. They can be more or less well documented and interesting for clinicians. The profusion of review articles on oxygen carriers contrasts with the little data from randomized controlled trials published recently.

– Jean-Franois Hardy

This article extensively (144 references) reviews the past, the present and the near future of hemoglobin-based oxygen carriers, emphasizing potential indications for these compounds in trauma (war and civilian) care.

– Philippe Van der Linden