This retrospective study showed a significantly higher mortality in burns children who received more total units of FFP during hospitalization (especially during their ICU stay and not for the surgical […]
This study represents the first of ten prospective clinical trials in oncology patients, which fails to show a benefit for the addition of intravenous iron to erythropoiesis-stimulating agents in improving […]
This observational cohort study of 102,470patients undergoing primary isolated CABG with cardiopulmonary bypass during calendar year 2008 at 798sites in the United States reports a wide variability in the rate […]
This prospective controlled randomized clinical trial strongly suggests that a restrictive transfusion strategy (target hematocrit: 24%) is as safe as a liberal transfusion strategy (target hematocrit: 30%) in patients undergoing […]
An excellent, well-documented review on transfusion-related acute lung injury (TRALI), referring to all the issues still being debated: definition, clinical presentation, incidence based on blood product transfusion, attempts at elucidating […]
In this randomized controlled trial during aortic surgery, requirements for allogeneic blood, prothrombin complex concentrates and recombinant factor VIIa were reduced in the ROTEM-guided group, while fibrinogen concentrate usage was […]
In their manuscript, Crispin et al. analyse different strategies (“contingency plans”) to effectively decrease transfusion demand in periods of 1)acute or longer lasting shortfall of the allogeneic blood supply (e.g. […]
The near 30% increase in transfusion use to treat anemia following the 2007 Decision Memo to restrict the initiation and target for ESA use for chemotherapy-induced anemia to 10g/dL is […]
Albumin versus various colloids including several HES preparations has been evaluated in many recent trials in cardiopulmonary bypass. This trial, reporting no difference between albumin and HES 130/0.4 on coagulation […]
In this paper, the authors report on the use of four parenteral iron products: ferric gluconate, iron sucrose, low-molecular-weight iron dextran (LMWID) and high-molecular-weight iron dextran (HMWID). They also analyze […]
In this retrospective study, the authors report that a well-defined blood conservation strategy can be associated with a decrease in allogeneic blood use and a reduction in the incidence of […]
Identification of surgical patients at high risk for requiring transfusion support is necessary to optimize perioperative management of bleeding complications. The observational study described by Ravn et al. is aimed […]
The authors present a very up-to-date review of the systemic and, in particular, the mircocirculatory effects of blood transfusions with special emphasis on the age of transfused RBCs. Maintenance of […]
Preoperative anemia in patients undergoing elective orthopedic surgery is associated with increased likelihood of blood transfusion as well as increased perioperative morbidity and mortality. A standardized approach for the detection, […]
The authors assessed whether FeSO4 supplementation (median of 39 days) impacted significantly on preoperative hemoglobin (Hb) levels and transfusion requirements in 103 patients undergoing surgery for colorectal cancer. They found […]