Updates in the management of severe coagulopathy in trauma patients.
This is a very good review on the pathophysiological changes which occur following trauma and the associated coagulopathy. Thrombo-cytopenia, hypotheromia, acidosis, and fibrinolysis are among factors which lead to coagulopathy. […]
Efficacy of recombinant factor VIIa administered by continuous infusion to haemophilia patients with inhibitors.
This is an interesting study looking at the efficacy of administering rFVIIa in controlling bleeding in 43 episodes in 14 hemophilia patients with inhibitors. RFVIIa infusion was not effective in […]
The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries.
This study illustrates one of the unusual situations in Medicine where evidence of drug efficacy in human preceded animal studies. After the publication of several case reports on the effectiveness […]
Massive blood transfusion in the elective surgical setting.
Nice overview, but inconsistency between recommendations in the figures and in the text. – V. Kretschmer
Orthopaedic surgery in haemophilic patients with inhibitors: an overview.
This is an excellent review on a large series reporting the use of rFVIIa in orthopedic surgeries in patients with hemophilia A and B with inhibitors, in addition to a […]
Continuous infusion of coagulation factor products.
This is an interesting review on the use of continuous infusion of coagulation factor products over the last 11 years. It concludes that effects were favorable in comparison to intermittent […]
Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threatening hemorrhage.
This article reports 2 patients with severe thrombocytopenia and severe hemorrhage which did not respond to standard therapy and platelet transfusion, but responded quickly to administration of a single dose […]
Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors.
This study reports the effective use of rFVIIa in covering 20 surgical procedures in 12 patients with hemophilia VIII with high inhibitors, in addition to treating 6 episodes of severe […]
Potential role for rFVIIa in transfusion medicine.
This a thorough and comprehensive review on the mechanism of action and various indications and uses of rFVIIa, highlighting the pivotal role of factor VII in hemostasis, as well as […]
Successful use of activated recombinant factor VII to control bleeding abnormalities in a patient with a left ventricular assist device.
This is a case report on effective hemostasis achieved after administering recombinant factor VIIa in a patient who had severe intra-operative and post-operative bleeding and severe hemostatic disturbances following cardiac […]
Mechanism of factor VIIa-dependent coagulation in hemophilia blood.
The mechanism of inducing hemostasis by factor VII (FVII) in hemophilia patients with inhibitors is not fully understood. Tissue factor (TF) and FVII are required to form a small concentration […]
Successful outcome of a cirrhotic patient with postoperative haematuria treated with a single high dose of recombinant factor VIIa.
Etiology of bleeding in patients with liver disease is multifactorial, and there has been variable response to treatment with rFVIIa, although correction of prolonged prothrombin time in such patients has […]
Use of recombinant factor VII in hepatology.
This article starts with a general overview on mechanism of action, uses and safety of rFVIIa as well as the hemostatic disorders which are associated with liver disease. It states […]
Rationale for the use of high dose rFVIIa in a high-titre inhibitor patient with haemophilia B during major orthopaedic procedures.
This is a case report of a child with severe hemophilia B and high titer factor IX inhibitor who was not achieving good hemostasis on conventional doses of rFVIIa. Pharmacokinetic […]
Off-label use of recombinant factor VIIa in patients following bone marrow transplantation.
This is a report on off-label extended use of rFVIIa in managing pulmonary, vesical and GI haemorrhage in 3 patients post-BMT, who failed to respond to blood component transfusion and […]